Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese Mice

Obesity-associated hyperglycemia underlies insulin resistance, glucose intolerance, and related metabolic disorders including type 2 diabetes, renal damage, nonalcoholic fatty liver disease. Turmeric root is commonly used in Asia, curcumin, one of its pharmacological components, can play a role preventing treating certain chronic physiological disorders. Accordingly, this study examined how high-fat diet (HFD)-induced hyperlipidemia are reduced by curcumin through changes scores, chromium distribution, injury mice. Relative to the control group, also fed an HFD, group weighed less had smaller adipocytes; it lower daily food efficiency, blood urea nitrogen creatinine levels, serum alanine aminotransferase aspartate hepatic triglyceride lipid regulation marker expression. The curcumin-treated obese exhibited significantly fasting glucose, was intolerant, higher Akt phosphorylation transporter 4 (GLUT4) expression, greater levels. Moreover, showed damage with TNF-? expression along more numerous antioxidative enzymes that included superoxide dismutase, glutathione peroxidase, catalase. histology mice superior infiltration fewer FASN PNPLA3 proteins comparison Curcumin contributed creating positive balance decreasing amount lost urine, leading mobilization needed mitigate hyperglycemia. Thus, results suggest prevents HFD-induced kidney injury,